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OPTN/SRTR 2021 Annual Data Report: Pancreas
Raja Kandaswamy1, Peter G Stock2, Jonathan M Miller3
1Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Surgery, University of Minnesota, Minneapolis, MN.
Pancreas transplant numbers remained stable in 2021, with increased transplants for type 2 diabetes patients and older recipients. Simultaneous pancreas-kidney transplants saw a slight decline, while outcomes remain best for this group.
Area of Science:
- Nephrology
- Transplantation Immunology
- Endocrinology
Background:
- Pancreas transplantation is a vital treatment for select patients with diabetes.
- The COVID-19 pandemic impacted organ transplantation rates globally.
- Understanding trends in pancreas transplantation is crucial for resource allocation and patient care.
Purpose of the Study:
- To analyze the trends in pancreas transplantation in the United States in 2021.
- To evaluate changes in patient demographics, transplant types, and center volume.
- To assess the outcomes of different types of pancreas transplants.
Main Methods:
- Retrospective analysis of pancreas transplant data from the United States in 2020 and 2021.
- Comparison of transplant volumes, patient demographics (type 2 diabetes, age), and transplant categories (simultaneous pancreas-kidney, pancreas-after-kidney, pancreas alone).
- Evaluation of 1-year graft failure rates for kidney and pancreas in simultaneous pancreas-kidney transplants.
Main Results:
- Total pancreas transplants remained stable (963 in 2021 vs. 962 in 2020).
- Proportion of transplants in type 2 diabetes patients increased (25.9% in 2021 vs. 21.3% in 2020).
- Transplants in older recipients (≥55 years) increased (13.5% in 2021 vs. 11.7% in 2020).
- Simultaneous pancreas-kidney transplants decreased slightly (820 vs. 827), while other categories increased.
- 1-year graft failure rates for 2020 simultaneous pancreas-kidney transplants were 5.7% for kidney and 10.5% for pancreas.
- Medium-volume centers performed a higher proportion of transplants (48.3% in 2021 vs. 35.1% in 2020).
Conclusions:
- Pancreas transplantation recovery lagged behind other organs post-pandemic.
- Shifting demographics include more type 2 diabetes patients and older recipients.
- Simultaneous pancreas-kidney transplants offer the best outcomes, despite a slight decrease in volume.
- There is a notable shift towards medium-volume centers performing pancreas transplants.
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