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Highly stable and fast-dissolving ascorbic acid-loaded microneedles.

Jeerapond Leelawattanachai1, Kedsara Panyasu1, Kornkanok Prasertsom1

  • 1National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.

International Journal of Cosmetic Science
|May 3, 2023
PubMed
Summary
This summary is machine-generated.

This study developed stable ascorbic acid microneedles using polyethyleneimine, enhancing skin delivery and stability. The new formulation shows potential for cosmetic and healthcare products.

Keywords:
ascorbic aciddelivery/vectorization/penetrationdissolving microneedleformulation/stabilitypolymerssafety testing

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Area of Science:

  • Materials Science
  • Dermatology
  • Biotechnology

Background:

  • Ascorbic acid offers skin benefits but faces challenges in topical delivery due to instability and poor skin penetration.
  • Microneedle technology presents a promising, minimally invasive method for delivering active compounds into the skin.

Purpose of the Study:

  • To formulate novel ascorbic acid-loaded microneedles with improved stability using polyethyleneimine.
  • To evaluate the microneedles' dissolution rate, skin penetration, biocompatibility, and antimicrobial properties.

Main Methods:

  • Fabrication of dextran-based microneedles loaded with ascorbic acid and varying concentrations of polyethyleneimine.
  • Assessment of ascorbic acid stability via DPPH assay, dissolution rate, skin penetration in porcine skin, biocompatibility (OECD TG No. 439), and antimicrobial activity.

Main Results:

  • 3.0% polyethyleneimine optimized microneedle formulation, significantly enhancing ascorbic acid stability (33% to 96% antioxidant activity after 8 weeks at 40°C).
  • Microneedles demonstrated rapid dissolution (within 2 minutes), effective skin penetration, biocompatibility, and broad-spectrum antimicrobial activity.

Conclusions:

  • The optimized ascorbic acid microneedle formulation exhibits enhanced stability and desirable properties.
  • This novel microneedle system holds significant potential for commercial application in cosmetics and healthcare.