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Updated: Jul 31, 2025

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Published on: July 26, 2024
Increased bioavailability of diosmetin-7-glucoside-γ-cyclodextrin inclusion complex compared with diosmin in
Masamitsu Moriwaki1, Kento Kito1, Ryo Nakagawa1
1Nutrition Division, Taiyo Kagaku Co. Ltd., Yokkaichi, Mie, Japan.
Abstract:
Diosmin (DSN) is found mainly in citrus fruits, and has potent antioxidant effects. This study aimed to evaluate pharmacokinetics of diosmetin-7-glucoside-γ-cyclodextrin (DIOSG-CD) inclusion complex. The area under the curve values from AUC0-24 of DIOSG-CD, prepared by reacting DSN and naringinase with γ-CD, were approximately 800-fold higher than those of DSN following their administration in Sprague-Dawley rats.
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