A sharing oocyte donation program: a 15-year cohort stud

Area of Science:

• Reproductive Medicine
• In Vitro Fertilization (IVF)
• Oocyte Donation

Background:

• Oocyte donation is a key pathway for individuals to access in vitro fertilization (IVF).
• It presents a viable option for recipients seeking pregnancy through assisted reproductive technologies.

Purpose of the Study:

• To evaluate and compare clinical and laboratory outcomes between oocyte donors and recipients.
• To assess the effectiveness of oocyte donation cycles in achieving successful pregnancies.

Main Methods:

• A retrospective cohort study analyzed 586 fresh oocyte donation cycles from 01/2002 to 12/2017.
• Outcomes from 290 donor cycles and 296 recipient cycles were analyzed, including 473 fresh embryo transfers.
• Statistical analysis involved Chi-square, Fisher's exact, Mann-Whitney U, and Student t-tests, with multivariate logistic regression.

Main Results:

• Fertilization rates were similar (72.0% donor vs. 74.6% recipient, p<0.001).
• Implantation rates (46.2% vs. 48.5%), clinical pregnancy rates (41.9% vs. 37.7%), and live birth rates (33.3% vs. 37.7%) were comparable between donors and recipients.
• Demographic and clinical factors in young, healthy donors/recipients did not significantly impact pregnancy outcomes.

Conclusions:

• Oocyte donation provides good and comparable results for both donors and recipients.
• Oocyte quality appears to be the primary determinant of success in intracytoplascitic sperm injection (ICSI) treatments.
• Oocyte-sharing programs are recommended as fair and effective options for fertility treatment.