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Updated: Jan 17, 2026
07:08
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
6.5K
Bisphenol A and human fertility: a systematic review
Carolina Paz Mohamad Isa1, Gabriela Barella Schmidt2, Renata Guerreiro de Jesus1
1Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
JBRA Assisted Reproduction
|September 23, 2025
Summary
Bisphenol A (BPA) exposure may negatively impact human fertility in both women and men. This review highlights BPA
Area of Science:
- Endocrinology
- Reproductive Toxicology
- Environmental Health
Background:
- Bisphenol A (BPA) is a synthetic compound with widespread human exposure.
- Emerging evidence suggests BPA's potential adverse effects on reproductive health.
Purpose of the Study:
- To review the scientific literature on the correlation between bisphenol A (BPA) exposure and human fertility.
- To synthesize current understanding of BPA's impact on male and female reproductive functions.
Main Methods:
- Bibliographic review of scientific articles.
- Analysis of studies investigating BPA exposure and reproductive outcomes.
Main Results:
- BPA exposure is linked to reduced ovarian reserve and impaired folliculogenesis in women.
- In pregnant women, BPA may increase risks of fetal malformations, spontaneous abortions, and premature births.
- In men, BPA exposure may decrease sperm production and contribute to testicular dysgenesis syndrome and cryptorchidism.
- BPA can disrupt hormonal balance, negatively affect assisted reproduction outcomes (ovarian response, fertilization, implantation), and lower estradiol levels.
Conclusions:
- Bisphenol A (BPA) poses a significant risk to human fertility.
- Further research is necessary to elucidate the complex mechanisms underlying BPA's reproductive toxicity.
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