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Birth after low-level +20 Aneuploid Mosaic Embryo Transfer: A Case Report
Marta Ribeiro Hentschke1,2, Aline Petracco Petzold2, Isadora Badalotti-Teloken2
1Fertilitat - Reproductive Medicine Center, Porto Alegre, RS, Brazil.
JBRA Assisted Reproduction
|February 21, 2024
Summary
Mosaic embryo transfer can lead to successful pregnancies. A case study shows a healthy baby born after transferring a mosaic embryo created using in vitro matured eggs and frozen sperm from percutaneous epididymal sperm aspiration (PESA).
Area of Science:
- Reproductive Medicine
- Embryology
- Genetics
Background:
- Mosaic embryo transfer is a debated topic in assisted reproductive technology.
- Azoospermia in males necessitates advanced sperm retrieval techniques.
- Next-generation sequencing (NGS) is crucial for accurate embryo genetic analysis.
Observation:
- A 40-year-old female and 37-year-old male presented with infertility.
- The male partner had azoospermia, requiring percutaneous epididymal sperm aspiration (PESA).
- Two IVF cycles were performed, with the second utilizing frozen PESA sperm and resulting in a mosaic embryo with 40% trisomy 20.
Findings:
- A mosaic embryo transfer resulted in a successful clinical pregnancy.
- The pregnancy culminated in the birth of a healthy baby girl.
- Postnatal karyotype analysis confirmed the baby's normal genetic status.
Implications:
- This case supports the potential viability of mosaic embryo transfers.
- Careful embryo selection and genetic analysis are vital for successful outcomes.
- Further research is warranted to establish guidelines for mosaic embryo utilization.
