Related Experiment Video
Updated: Jul 31, 2025
06:06
The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
Published on: December 14, 2020
3.5K
Do flies dream of protein? How the gut regulates sleep depth
Zita Carvalho-Santos1, Carlos Ribeiro2
1Instituto de Medicina Molecular João Lobo Antunes (iMM), Lisbon, Portugal.
Cell Metabolism
|May 3, 2023
Abstract:
A recent study by Titos et al. in Cell shows that protein-rich diets are strong modulators of sleep depth in Drosophila and identifies the gut-secreted neuropeptide CCHa1 as the mediator of this effect. In the brain, CCHa1 controls dopamine release from a small set of neurons, thereby modulating arousability by integrating internal state with sensory information.
Related Concept Videos
02:19Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
01:11Understanding Sleep
441
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
441