Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

88
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
88
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Residuals and Least-Squares Property01:11

Residuals and Least-Squares Property

7.5K
The vertical distance between the actual value of y and the estimated value of y. In other words, it measures the vertical distance between the actual data point and the predicted point on the line
If the observed data point lies above the line, the residual is positive, and the line underestimates the actual data value for y. If the observed data point lies below the line, the residual is negative, and the line overestimates the actual data value for y.
The process of fitting the best-fit...
7.5K
Calibration Curves: Linear Least Squares01:20

Calibration Curves: Linear Least Squares

1.4K
A calibration curve is a plot of the instrument's response against a series of known concentrations of a substance. This curve is used to set the instrument response levels, using the substance and its concentrations as standards. Alternatively, or additionally, an equation is fitted to the calibration curve plot and subsequently used to calculate the unknown concentrations of other samples reliably.
For data that follow a straight line, the standard method for fitting is the linear...
1.4K
Parametric Survival Analysis: Weibull and Exponential Methods01:14

Parametric Survival Analysis: Weibull and Exponential Methods

501
Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
501
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

100
Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
100

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wavelet Decomposition-Based Genomic Analysis of the Human Electrocardiogram.

medRxiv : the preprint server for health sciences·2026
Same author

Quantifying Anterior Cruciate Ligament Injury Resilience: A Screening and Composite Score Framework.

Orthopaedic journal of sports medicine·2026
Same author

Epithelial-Mesenchymal Wnt Crosstalk Directs Planar Cell Polarity in the Developing Cochlea.

bioRxiv : the preprint server for biology·2026
Same author

Prognostic pan-cancer and single-cancer models: A large-scale analysis using a real-world clinico-genomic database.

PloS one·2026
Same author

Benzimidazole derivatives as anticancer agents: a comprehensive review of their synthesis, mechanism, and clinical potential.

Future medicinal chemistry·2025
Same author

Estimating heterogeneous treatment effects for general responses.

Biometrics·2025
Same journal

ebnm: An R Package for Solving the Empirical Bayes Normal Means Problem Using a Variety of Prior Families.

Journal of statistical software·2026
Same journal

Optimum Allocation for Adaptive Multi-Wave Sampling in R: The R Package optimall.

Journal of statistical software·2025
Same journal

BoXHED2.0: Scalable Boosting of Dynamic Survival Analysis.

Journal of statistical software·2025
Same journal

Probabilistic Estimation and Projection of the Annual Total Fertility Rate Accounting for Past Uncertainty: A Major Update of the bayesTFR R Package.

Journal of statistical software·2024
Same journal

PResiduals: An R Package for Residual Analysis Using Probability-Scale Residuals.

Journal of statistical software·2024
Same journal

Regression Modeling for Recurrent Events Possibly with an Informative Terminal Event Using R Package reReg.

Journal of statistical software·2024
See all related articles

Related Experiment Video

Updated: Jul 31, 2025

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.4K

Elastic Net Regularization Paths for All Generalized Linear Models.

J Kenneth Tay1, Balasubramanian Narasimhan2, Trevor Hastie2

  • 1Department of Statistics, Stanford University, 390 Jane Stanford Way, Stanford, California 94305, United States of America.

Journal of Statistical Software
|May 4, 2023
PubMed
Summary
This summary is machine-generated.

The elastic net regularization method now supports a wider range of generalized linear and Cox models, including complex survival data. This advancement offers more flexible tools for supervised learning and model performance evaluation.

Keywords:
Cox modelcoordinate descentelastic netgeneralized linear modelslassoregularization pathsurvivalℓ1 penalty

More Related Videos

Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.2K
Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.2K

Related Experiment Videos

Last Updated: Jul 31, 2025

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.4K
Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.2K
Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.2K

Area of Science:

  • Statistical modeling
  • Machine learning
  • Computational statistics

Background:

  • Lasso and elastic net are established regularized regression techniques.
  • Previous algorithms efficiently computed elastic net paths for OLS, logistic, and multinomial logistic regression.
  • Extensions existed for Cox models with right-censored data.

Purpose of the Study:

  • To extend elastic net regularization to a broader class of models.
  • To incorporate Cox models with interval-censored data and strata.
  • To introduce a simplified relaxed lasso and utility functions for model evaluation.

Main Methods:

  • Algorithm extension for generalized linear models (GLMs).
  • Adaptation for Cox models with start-stop data and strata.
  • Implementation of a simplified relaxed lasso algorithm.
  • Development of model performance assessment utilities.

Main Results:

  • Successful extension of elastic net regularization to all GLM families.
  • Capability to handle Cox models with interval-censored data and strata.
  • Availability of a simplified relaxed lasso.
  • Inclusion of practical functions for model performance evaluation.

Conclusions:

  • The elastic net framework is now more versatile, covering a wider array of statistical models.
  • These extensions provide enhanced capabilities for analyzing complex and censored survival data.
  • The updated methods and utilities facilitate more robust supervised learning and model selection.