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Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish

Hui Lv1, Bo Liu2, Yongwen Qin3

  • 1Department of Cardiovascular Disease, The Second Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.

Mediators of Inflammation
|May 4, 2023
PubMed
Abstract

Insights

Cardiovascular drugs like isosorbide mononitrate and rosuvastatin calcium may impact blood vessel formation (angiogenesis) via the VEGF pathway, potentially improving cardiovascular disease treatment.

Area of Science:

  • Cardiovascular Research
  • Developmental Biology
  • Pharmacology

Background:

  • Angiogenesis is integral to cardiovascular disease (CVD) pathophysiology.
  • Certain cardiovascular drugs influence angiogenesis.

Purpose of the Study:

  • To investigate the in vivo effects of cardiovascular drugs on angiogenesis during vertebral development.
  • To identify specific cardiovascular drugs that modulate angiogenesis.

Main Methods:

  • Utilized transgenic Tg (flk1: EGFP) zebrafish embryos for in vivo angiogenesis studies.
  • Exposed zebrafish embryos to cardiovascular drugs in embryo medium with 0.5% DMSO for 24 hours.

Main Results:

  • Identified six drugs affecting angiogenesis: isosorbide mononitrate, amlodipine, bisoprolol fumarate, carvedilol, irbesartan, and rosuvastatin calcium.
  • These drugs potentially influence angiogenesis through the vascular endothelial growth factor (VEGF) signaling pathway.

Conclusions:

  • Findings suggest specific cardiovascular drugs can modulate angiogenesis.
  • These insights may lead to improved therapeutic strategies for cardiovascular diseases.

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