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Updated: Jul 31, 2025
09:56
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
686
mRNA delivery in cancer immunotherapy
Yichen Zhong1,2, Shi Du1,2, Yizhou Dong1,3,2
1Division of Pharmaceutics & Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Acta Pharmaceutica Sinica. B
|May 4, 2023
Summary
Messenger RNA (mRNA) shows promise for cancer immunotherapy. Nanoparticles are crucial for delivering mRNA, overcoming challenges like instability and poor cellular uptake for effective cancer treatment.
Area of Science:
- Biomedical Engineering
- Oncology
- Drug Delivery Systems
Background:
- Messenger RNA (mRNA) is emerging as a significant therapeutic modality in oncology.
- Challenges in mRNA therapy include its inherent instability and inefficient cellular delivery.
- Nanoparticle-based delivery systems are being developed to enhance mRNA efficacy.
Purpose of the Study:
- To review nanoparticle platforms for mRNA delivery in cancer immunotherapy.
- To discuss the role of different nanoparticle types in enhancing mRNA-based cancer treatments.
- To highlight clinical advancements and future directions in mRNA cancer therapy.
Main Methods:
- Review of current literature on nanoparticle systems for mRNA delivery.
- Categorization of nanoparticles into lipid, polymer, lipid-polymer hybrid, and protein/peptide-mediated systems.
- Analysis of the application of these systems in cancer immunotherapy.
Main Results:
- Nanoparticles significantly improve mRNA stability and cellular uptake.
- Four main categories of nanoparticles (lipid, polymer, hybrid, protein/peptide) are effective for mRNA delivery.
- These systems facilitate mRNA-based cancer immunotherapies with promising clinical translation.
Conclusions:
- Nanoparticle engineering is vital for overcoming mRNA delivery barriers in cancer treatment.
- Various nanoparticle platforms offer tailored solutions for mRNA-based cancer immunotherapies.
- Continued research and clinical translation are expected to advance mRNA therapeutics for cancer.
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