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Splenic function: normal, too much and too little.

E R Eichner

    The American Journal of Medicine
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    This review covers normal spleen function, splenomegaly, and hypersplenism. It also details spleen removal indications and hyposplenism risks, including life-threatening infections in patients lacking spleen function.

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    Area of Science:

    • Hematology
    • Immunology
    • Surgical Pathology

    Background:

    • The spleen plays a crucial role in immune surveillance and blood filtration.
    • Enlargement of the spleen (splenomegaly) and overactive spleen function (hypersplenism) can lead to various clinical issues.
    • Understanding splenic function is vital for managing related disorders.

    Purpose of the Study:

    • To provide a comprehensive overview of normal splenic function.
    • To elucidate the mechanisms and consequences of splenomegaly and hypersplenism.
    • To discuss indications for splenectomy and the implications of hyposplenism.

    Main Methods:

    • Literature review of splenic physiology and pathology.
    • Analysis of clinical consequences of altered splenic function.

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  • Examination of surgical indications and post-splenectomy risks.

    • Main Results:

    • Detailed explanation of splenic roles in immunity and hematology.
    • Description of pathological conditions like splenomegaly and hypersplenism.
    • Identification of medical indications for spleen removal and management of hyposplenism.

    Conclusions:

    • Splenic function is critical for immune defense and blood homeostasis.
    • Splenomegaly and hypersplenism necessitate careful management.
    • Hyposplenic or asplenic patients face significant risks of severe infections, particularly septicemia, requiring vigilant monitoring and prophylactic measures.