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[Effect of tiropramide on solid gastric emptying time in man]
Minerva Medica
|April 21, 1986
Summary
Thyropramide, a new spasmolytic, did not significantly alter gastric emptying times in healthy adults. This study suggests Thyropramide may act on the large intestine without affecting stomach motility.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Gastric emptying is crucial for nutrient absorption and digestive processes.
- Spasmolytics are used to relieve smooth muscle spasms, but their effects on gastric motility vary.
Purpose of the Study:
- To assess the influence of Thyropramide on gastric emptying times of a solid meal in healthy subjects.
- To determine if Thyropramide affects proximal or distal stomach function.
Main Methods:
- A placebo-controlled study was conducted on 10 healthy volunteers (aged 23-54).
- Subjects received Thyropramide (300 mg/day for 3 days) or a placebo orally.
- Gastric emptying times for a solid meal were measured.
Main Results:
- Thyropramide did not significantly modify gastric emptying time compared to placebo.
- A slight, non-significant average increase in half-emptying time (T 1/2) was observed.
- No adverse side effects were reported during the study.
Conclusions:
- Thyropramide appears to exert a spasmolytic effect on the large intestine.
- Thyropramide does not influence stomach motility, either proximally or distally.