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Dipeptide-polysaccharides hydrogels through co-assembly.

Tan Hu1, Yang Xu2, Gang Xu2

  • 1Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; College of Food Science and Technology, Huazhong Agricultural University, No. 1 Shizishan Road, Wuhan, Hubei 430070, China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, China.

Food Chemistry
|May 4, 2023
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Summary
This summary is machine-generated.

Researchers developed stronger peptide hydrogels by combining a modified dipeptide with natural polysaccharides like Arabic gum and citrus pectin. These biocompatible hydrogels show promise for drug delivery applications.

Keywords:
Co-assemblyDipeptideEncapsulationHydrogelsPolysaccharides

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Area of Science:

  • Supramolecular chemistry
  • Materials science
  • Biomedical engineering

Background:

  • Dipeptide hydrogels are promising for various applications but often suffer from weak mechanical properties.
  • Enhancing the stability and mechanical strength of self-assembling peptide hydrogels is crucial for their practical use.

Purpose of the Study:

  • To improve the mechanical properties and stability of alkyl-chain modified dipeptide hydrogels.
  • To explore the co-assembly of a modified dipeptide with polysaccharides for enhanced hydrogel formation.
  • To evaluate the potential of these novel hydrogels for drug encapsulation and delivery.

Main Methods:

  • Co-assembly of alkyl-chain modified dipeptide (C13-tryptophan-tyrosine, C13-WY) with Arabic gum and citrus pectin.
  • Characterization of hydrogel mechanical properties (G' value) and stability.
  • Analysis of molecular structure, including beta-sheet content and hydrogen bonding.
  • Assessment of hydrogel cytotoxicity.
  • Evaluation of docetaxel encapsulation efficiency and release kinetics.

Main Results:

  • Co-assembled C13-WY-arabic gum and C13-WY-pectin hydrogels exhibited significantly enhanced mechanical properties (3x and 10x increase in G' value, respectively) compared to C13-WY hydrogels alone.
  • The addition of polysaccharides induced co-assembly and molecular rearrangement, leading to increased beta-sheet structure and hydrogen bonds.
  • The developed hydrogels demonstrated low cytotoxicity.
  • High encapsulation rate and sustained release of docetaxel were achieved using these hydrogels.

Conclusions:

  • Co-assembly with Arabic gum and citrus pectin is an effective strategy to create stable, mechanically robust supramolecular peptide hydrogels.
  • These novel hydrogels possess good biocompatibility and are suitable for controlled drug delivery applications.
  • The findings offer a new approach for designing advanced peptide-based biomaterials.