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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Factor VII Deficiency and Second Trimester Abortion: A Case Report

Katie P Nguyen1, Tamara Lynne B Aqui2, Honey Milestone3

  • 1Family Medicine, Riverside Community Hospital, Riverside, USA.

Cureus
|May 5, 2023
PubMed

The prevalence of factor VII deficiency (F7D) is 1 in 500,000. Due to its rarity, the management of bleeding disorders in pregnancy is not well established. We examine a case of an 18-year-old (gravida 1, para 0) woman at approximately 19 weeks gestation with a known history of F7D who presents after a motor vehicle accident. Fetal demise was confirmed necessitating a medical induction. She also had multiple fractures requiring surgical intervention. A multidisciplinary team consisting of orthopedic surgery, obstetrics and gynecology, and hematology/oncology was consulted for optimal timing of factor VII replacement prior to procedures. The patient underwent successful left tibial intramedullary nailing with minimal bleeding. She received factor VII and tolerated an uncomplicated vaginal delivery. Her postpartum and postoperative courses were uncomplicated, requiring one unit of packed red blood cells. The patient was discharged on postpartum day three. Management of this second-trimester abortion with a history of F7D was possible with effective communication and the organization of a multidisciplinary team to account for the risk of thrombosis versus hemorrhage and the availability of factor VII replacement therapy.

Keywords:
factor vii deficiencyhematologyinduced abortionsurgerytrauma

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