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Updated: Jul 31, 2025

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
Published on: May 10, 2024
Endoscopic negative pressure therapy for duodenal leaks
Dörte Wichmann1,2,3, Dietmar Stüker1,2, Ulrich Schweizer1,2,3
1Department of General, Visceral and Transplantation Surgery at the University Hospital of Tübingen, Tübingen, Germany.
Endoscopic negative pressure therapy (ENPT) effectively treats duodenal leaks and stump insufficiencies. This method shows success in managing duodenal perforations, offering a viable therapeutic option.
Area of Science:
- Gastroenterology
- Surgical Innovation
- Endoscopic Therapeutics
Background:
- Endoscopic negative pressure therapy (ENPT) is established for upper and lower GI tract perforations.
- Limited data exists for duodenal perforations, primarily case reports.
- ENPT indications in the duodenum include primary leaks, post-surgical management, and recurrent anastomotic insufficiency.
Purpose of the Study:
- To evaluate the efficacy of ENPT in duodenal perforations.
- To present a case series and review literature on endoscopic negative pressure duodenal therapy.
Main Methods:
- Retrospective analysis of a 4-year case series of ENPT for duodenal conditions.
- Comprehensive literature review of endoscopic negative pressure duodenal therapy.
Main Results:
- Included 10 patients: 6 with primary duodenal leaks and 4 with duodenal stump insufficiencies.
- ENPT was the primary and sole therapy in 7 patients.
- Mean ENPT duration was 11.0 days; mean hospital stay was 30.0 days. Re-operation was needed in 2 patients.
Conclusions:
- ENPT demonstrates high success rates in treating duodenal leaks.
- Challenges include probe length and maintaining device position amidst intestinal motility.
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