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Epigenetic regulation of stem cells in lung cancer oncogenesis and therapy resistance

Jiayang Wu1, Jiaming Feng2, Qiran Zhang1

  • 1Department of Pulmonary and Critical Care Medicine, Med-X Center for Manufacturing, Center of Precision Medicine, Precision Medicine Key Laboratory of Sichuan Province, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.

Frontiers in Genetics
|May 5, 2023
PubMed

Insights

Epigenetics influences lung cancer development and treatment resistance by affecting stem cell signaling. Understanding these epigenetic mechanisms offers new therapeutic strategies for lung cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Stem Cell Biology

Background:

  • Epigenetics is crucial for stem cell signaling and is implicated in lung cancer oncogenesis and therapeutic resistance.
  • Lung cancer arises from aberrant stem/progenitor cell differentiation, with subtypes linked to cell of origin.
  • Cancer treatment resistance in lung cancer is associated with lung cancer stem cells exploiting normal stem cell functions.

Purpose of the Study:

  • To review the principles of epigenetic regulation of stem cell signaling in lung cancer.
  • To explore the role of epigenetics in lung cancer development and therapeutic resistance.
  • To discuss the impact of the tumor immune microenvironment and future epigenetic therapies.

Main Methods:

  • Literature review of epigenetic mechanisms in lung cancer.
  • Analysis of stem cell signaling pathways in oncogenesis.
  • Examination of studies on cancer stem cells and therapeutic resistance.
  • Inclusion of research on tumor immune microenvironment and epigenetics-based therapies.

Main Results:

  • Epigenetic regulation of stem cell signaling is central to lung cancer initiation and progression.
  • Lung cancer stem cells contribute to therapeutic resistance through drug transport, DNA repair, and niche protection.
  • The tumor immune microenvironment interacts with epigenetic regulatory pathways in lung cancer.

Conclusions:

  • Epigenetic mechanisms are key drivers in lung cancer pathogenesis and resistance.
  • Targeting epigenetic regulation presents a promising avenue for novel lung cancer treatments.
  • Future research into epigenetics-related strategies holds potential for improved lung cancer therapy.
Keywords:
epigeneticslung canceroncogenesisstem cellstherapy resistancetumor microenvironment

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