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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
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Endoprosthetic reconstruction for lower extremity soft tissue sarcomas with bone involvement
P D Rowell1, P C Ferguson1, K M Tsoi1
1University of Toronto Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada.
Journal of Surgical Oncology
|May 5, 2023
Summary
Endoprosthetic reconstruction (EPR) for lower extremity soft tissue sarcoma (STS) is challenging. This study found EPRs for STS have high complication rates, including infection, and are associated with lower survival outcomes.
Area of Science:
- Orthopedic Oncology
- Surgical Oncology
- Musculoskeletal Oncology
Background:
- Management of soft tissue sarcoma (STS) involving bone resection and endoprosthetic reconstruction (EPR) presents unique challenges.
- This cohort represents a rare and previously undocumented group undergoing EPR for lower extremity STS.
Purpose of the Study:
- To report on the surgical and oncological outcomes of patients undergoing EPR for lower extremity STS.
- To evaluate the complication rates and survival associated with EPR in this specific patient population.
Main Methods:
- A single-center retrospective review of prospectively collected data.
- Inclusion criteria were applied to 29 patients who underwent EPR following resection of primary lower extremity STS.
Main Results:
- The study included 29 patients (mean age 54 years) with various femur EPR locations.
- Nearly half (48%) of patients required re-operations, primarily for infection (31%).
- A matched cohort analysis revealed reduced overall survival and metastasis-free survival in patients requiring EPR compared to those who did not.
Conclusions:
- Endoprosthetic reconstruction for STS is associated with a high incidence of complications, including surgical site infections.
- Patients undergoing EPR for STS should be informed of the elevated risks of complications and potentially poorer survival outcomes.
