Related Experiment Video
Updated: Jul 31, 2025

09:25
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
19.2K
[Primordial odontogenic tumor in children]
S V Yakovlev1, O Z Topolnitsky1, D A Lezhnev1
1Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
Summary
The first Russian pediatric cases of primordial odontogenic tumor (POT), a rare benign tumor, are presented. Comprehensive examination and surgical treatment confirmed the diagnosis morphologically.
Area of Science:
- Oral pathology
- Odontogenic tumors
- Pediatric dentistry
Context:
- Primordial odontogenic tumor (POT) is a rare benign mixed epithelial and mesenchymal odontogenic tumor.
- POT was newly classified in the 2017 World Health Organization (WHO) classification.
- This study presents the first two clinical cases of POT treatment in children in Russia.
Purpose:
- To inform maxillofacial surgeons and dentists about the clinical, radiological, and morphological features of POT.
- To share clinical experience and literature data on POT management.
- To contribute to the understanding of this rare odontogenic tumor in pediatric patients.
Summary:
- Two pediatric patients with primordial odontogenic tumor (POT) underwent comprehensive examination and surgical treatment.
- Diagnosis was confirmed morphologically.
- This report details the clinical, radiological, and morphological findings in these cases.
Impact:
- Enhances understanding of primordial odontogenic tumors in pediatric populations.
- Provides valuable clinical insights for maxillofacial surgeons and dentists.
- Contributes to the literature on rare odontogenic tumors and their management.
Related Concept Videos
Teeth
519
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
519
The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
Tooth Anatomy
594
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
594
Bone Formation by Endochondral Ossification
4.8K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.8K
Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
Bone Formation by Intramembranous Ossification
6.5K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
6.5K

