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Biosensors for prostate cancer detection.

Sattar Akbari Nakhjavani1, Begum K Tokyay2, Cansu Soylemez3

  • 1Department of Mechanical Engineering, Koç University, Sariyer, Istanbul 34450, Turkey; Koç University Translational Medicine Research Center (KUTTAM), Koç University, Istanbul 34450, Turkey.

Trends in Biotechnology
|May 5, 2023
PubMed
Summary

Prostate cancer (PC) detection is crucial. This review discusses advanced biosensing platforms, including immunosensors and microfluidic systems, to overcome limitations in current point-of-care (POC) diagnostics for PC biomarkers.

Keywords:
biomarkersbiosensorshealthcarepoint of careprostate cancer

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Oncology

Background:

  • Prostate cancer (PC) is a significant global health concern, causing substantial mortality in men.
  • Accurate and rapid detection of PC biomarkers is essential for timely diagnosis and treatment.
  • Current analytical methods face challenges, particularly in point-of-care (POC) settings, necessitating improved technologies.

Purpose of the Study:

  • To review and discuss various biosensing platforms for prostate cancer (PC) biomarker detection.
  • To highlight advancements in biosensor technologies addressing limitations in current diagnostic methods.
  • To explore emerging platforms for practical and efficient PC biomarker analysis.

Main Methods:

  • Review of existing literature on biosensors for PC biomarker detection.
  • Discussion of electrochemical (EC), optical, and magnetic biosensor principles.
  • Exploration of novel biosensing platforms: immunosensors, aptasensors, genosensors, paper-based devices, microfluidic systems, and multiplex platforms.

Main Results:

  • Various biosensing platforms show promise for detecting PC biomarkers.
  • Electrochemical, optical, and magnetic biosensors offer quantitative and rapid detection capabilities.
  • Emerging technologies aim to improve sample preparation and overall practicality for POC applications.

Conclusions:

  • Biosensing platforms offer advanced solutions for prostate cancer biomarker detection.
  • New technologies are enhancing the sensitivity, speed, and practicality of PC diagnostics.
  • Continued development of these platforms holds significant potential for improving patient outcomes.