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CRISPR

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...

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Related Experiment Video

Updated: Jan 14, 2026

Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases

Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases

Published on: August 16, 2024

CRISPR-on-Chip for Point-of-Care Diagnostics.

Nazente Atceken^1,2,3,4,5, Alptekin Kahya¹, Defne Yigci³

¹School of Biomedical Sciences and Engineering, Koç University, Istanbul 34450, Turkey.

|January 13, 2026

Summary

This summary is machine-generated.

CRISPR-on-chip technology integrates CRISPR-Cas diagnostics with microfluidics for advanced point-of-care applications. This review highlights its potential in infectious disease detection and personalized medicine.

Keywords:

CRISPR-based diagnostic CRISPR-on-chip technology microfluidics point-of-care (PoC)

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Area of Science:

Biotechnology and Biomedical Engineering
Molecular Diagnostics
Nanotechnology

Background:

CRISPR-based diagnostic platforms offer high sensitivity and specificity for detecting pathogens and diseases.
Point-of-care (PoC) applications are increasingly adopting these platforms due to their practical advantages.
CRISPR-Cas technology is widely used, but its integration with microfluidics for PoC diagnostics requires further understanding.

Purpose of the Study:

To review recent advancements in CRISPR-on-chip diagnostic technologies.
To highlight the potential applications of CRISPR-on-chip in infectious diseases, biosensors, and personalized medicine.
To discuss challenges and future perspectives for developing ideal diagnostic solutions.

Main Methods:

Integration of CRISPR-Cas systems with microfluidic devices to create CRISPR-on-chip platforms.
Review of existing literature on CRISPR-on-chip technology and its applications.
Analysis of the advantages, challenges, and future directions of CRISPR-on-chip diagnostics.

Main Results:

CRISPR-on-chip platforms enable scalable, portable, real-time, and precise biomolecule detection.
These platforms offer single-molecule sensitivity, multiplex detection capabilities, and enhanced diagnostic accuracy.
CRISPR-on-chip technology reduces processing times and the need for extensive laboratory infrastructure.

Conclusions:

CRISPR-on-chip technology represents a significant advancement in diagnostics, particularly for PoC applications.
The technology holds great promise for rapid detection of infectious diseases and enabling personalized medicine.
Addressing integration challenges is crucial for realizing the full potential of CRISPR-on-chip for ideal diagnostic solutions.