Related Experiment Video
Updated: Jul 31, 2025
12:48
Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
Published on: August 21, 2017
8.3K
Trogocytosis and cross-dressing in antigen presentation
Patrick Schriek1, Jose A Villadangos2
1Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia.
Current Opinion in Immunology
|May 6, 2023
Summary
Trogocytosis allows cells to acquire and display foreign antigens and MHC molecules from other cells. This process, known as cross-dressing, expands cellular immune functions with varied outcomes.
Area of Science:
- Immunology
- Cell Biology
Background:
- Antigen-presenting cells (APCs) typically present peptides bound to their own Major Histocompatibility Complex (MHC) molecules.
- A novel mechanism allows cells to present antigens they did not synthesize themselves.
Purpose of the Study:
- To review the process of trogocytosis and its role in antigen presentation.
- To explore the phenomenon of cross-dressing where cells acquire and display foreign MHC-antigen complexes.
Main Methods:
- Review of existing literature on trogocytosis and cross-dressing.
- Analysis of cellular mechanisms involved in fragment acquisition and membrane incorporation.
Main Results:
- Trogocytosis enables cells to acquire fragments from other living cells without harming the donor.
- The acquired fragments can include intact antigens and MHC molecules, leading to cross-dressing.
- Cross-dressed cells can present foreign antigens and MHC molecules.
Conclusions:
- Trogocytosis and cross-dressing significantly expand the immunological repertoire of both immune and non-immune cells.
- These processes have both beneficial and deleterious consequences in various immunological contexts.
Related Concept Videos
01:22Antigen Presenting Cells
1.9K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
1.9K
01:31Antigen Processing Pathways
1.1K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
1.1K
01:26Antigens Involved in Adaptive Immunity
580
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
580
01:15Transcytosis of IgG
2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K
01:22T Cell Activation and Clonal Selection
854
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
854
01:28Diversity of Antigen Receptors
678
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
678