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Photobiomodulation: An Emerging Treatment Modality for Depression.

Willians Fernando Vieira1, Dan V Iosifescu2, Kayla Marie McEachern3

  • 1Division of Neuropsychiatry and Neuromodulation, Massachusetts General Hospital (MGH), 149 13th Street (2612), Boston, MA 02129, USA; Department of Psychiatry, Harvard Medical School (HMS), 25 Shattuck Street, Boston, MA 02115, USA; Department of Anatomy, Institute of Biomedical Sciences (ICB), University of Sao Paulo (USP), 2415 Prof. Lineu Prestes Avenue, Sao Paulo, SP 05508-000, Brazil.

The Psychiatric Clinics of North America
|May 6, 2023
PubMed
Summary

Transcranial photobiomodulation (t-PBM) shows promise for treating major depressive disorder (MDD), especially for treatment-resistant depression (TRD). This therapy uses near-infrared light to modulate brain activity, offering a potential alternative for patients unresponsive to traditional treatments.

Keywords:
LLLTMajor depressive disorderNIRPhotobiomodulationTranscranial photobiomodulationTreatment-resistant depression

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Biomedical Engineering

Background:

  • Major depressive disorder (MDD) is a significant global health concern.
  • Many patients with MDD do not respond adequately to conventional treatments like pharmacotherapy and psychotherapy, leading to a diagnosis of treatment-resistant depression (TRD).
  • Novel therapeutic approaches are needed for individuals with TRD.

Purpose of the Study:

  • To review the antidepressant effects of transcranial photobiomodulation (t-PBM) therapy.
  • To specifically evaluate the efficacy of t-PBM in patients diagnosed with treatment-resistant depression (TRD).

Main Methods:

  • A systematic literature search was conducted on PubMed and ClinicalTrials.gov.
  • The search focused on clinical studies investigating the use of t-PBM for treating MDD and TRD.
  • Data from these studies were analyzed to assess treatment outcomes.

Main Results:

  • Preliminary evidence suggests that t-PBM may have antidepressant effects.
  • The review highlights the potential of t-PBM as a therapeutic option for TRD.
  • Further research is warranted to establish optimal parameters and long-term efficacy.

Conclusions:

  • Transcranial photobiomodulation (t-PBM) represents a promising non-invasive neuromodulation technique for major depressive disorder (MDD).
  • t-PBM therapy warrants further investigation as a potential treatment for treatment-resistant depression (TRD).
  • The findings support continued research into t-PBM for psychiatric disorders.