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Adalimumab Therapeutic Drug Monitoring Improves Treatment Outcome in Patients with Psoriasis
Afsaneh Alavi1, Edward V Loftus2
1Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
Abstract:
Therapeutic drug monitoring (TDM) or the measurement of drug concentrations (ideally at trough level) and antidrug antibodies are important tools for optimizing biologic therapy. Limited studies evaluated TDM in dermatological indications. A retrospective study of 170 patients with psoriasis who were treated with adalimumab and received TDM reported that adalimumab TDM is practical and promising in routine psoriasis care. However, TDM interpretation requires careful attention to the clinical context to address the controversies and challenges.
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