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Crosstalk between N6-methyladenosine (m6A) modification and noncoding RNA in tumor microenvironment
Dan Wang1, Yingying Han1, Lushan Peng1
1Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
International Journal of Biological Sciences
|May 8, 2023
Summary
N6-methyladenosine (m6A) modification and non-coding RNAs (ncRNAs) interact within the tumor microenvironment (TME). This crosstalk influences tumor progression and offers potential as diagnostic markers for precise cancer therapy.
Area of Science:
- Molecular Biology
- Cancer Research
- Epigenetics
Background:
- N6-methyladenosine (m6A) is a prevalent RNA modification regulating gene expression in eukaryotes.
- m6A and non-coding RNAs (ncRNAs) are implicated in various diseases, including cancer.
- The tumor microenvironment (TME) critically influences tumor development and progression.
Purpose of the Study:
- To review the interplay between m6A modification-associated ncRNAs and the TME.
- To analyze the impact of m6A-related ncRNAs on tumor proliferation, angiogenesis, invasion, metastasis, and immune escape.
- To highlight the potential of m6A-related ncRNAs as biomarkers for tumor detection and liquid biopsy.
Main Methods:
- Literature review and analysis of existing studies.
- Synthesis of current knowledge on m6A modification and ncRNA functions in the TME.
- Exploration of the regulatory roles of m6A-modified ncRNAs in cancer biology.
Main Results:
- m6A modification regulates the production, stability, and degradation of ncRNAs.
- ncRNAs, in turn, modulate the expression of m6A-related proteins.
- The crosstalk between m6A and ncRNAs significantly impacts TME biological regulation.
- m6A-related ncRNAs influence tumor proliferation, angiogenesis, invasion, metastasis, and immune escape.
Conclusions:
- m6A-related ncRNAs are crucial regulators within the TME.
- These ncRNAs show promise as diagnostic markers for tumor tissue samples.
- Exosomal m6A-related ncRNAs represent potential biomarkers for liquid biopsy.
- Understanding this relationship is vital for developing novel, precise cancer therapies.
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