Aryl fluorosulfates: powerful and versatile partners in cross-coupling reactions
Shelesh Krishna Saraswat1, Ramanjaneyulu Seemaladinne2, Media Noori Abdullah3
1Department of ECE, Gla University Mathura India.
RSC Advances
|May 8, 2023
Summary
Aryl fluorosulfates are versatile reagents in organic synthesis, offering a greener alternative to triflates in cross-coupling reactions. This review highlights their growing importance in Sulfur Fluoride Exchange (SuFEx) click chemistry and various coupling applications.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Aryl fluorosulfates are key building blocks in modern organic synthesis.
- They are increasingly utilized in Sulfur Fluoride Exchange (SuFEx) click chemistry.
- These compounds offer advantages over traditional reagents like triflates.
Purpose of the Study:
- To review recent advancements in the application of aryl fluorosulfates.
- To highlight their role as electrophilic partners in cross-coupling reactions.
- To discuss their synthesis from phenols using sulfuryl fluoride.
Main Methods:
- Literature review of recent studies on aryl fluorosulfates.
- Focus on their use in carbon-carbon and carbon-heteroatom cross-coupling.
- Emphasis on synthesis from phenols and sulfuryl fluoride.
Main Results:
- Aryl fluorosulfates are effective electrophilic partners in various cross-coupling reactions.
- They serve as less toxic and more atom-economical alternatives to triflates.
- Their preparation from phenols using sulfuryl fluoride is efficient and cost-effective.
Conclusions:
- Aryl fluorosulfates represent a significant development in synthetic organic chemistry.
- Their versatility and favorable properties promote their wider adoption in SuFEx click chemistry and cross-coupling.
- Continued research is expected to expand their synthetic utility.
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