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Related Concept Videos

Alterations in Blood Pressure01:30

Alterations in Blood Pressure

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Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
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Factors affecting Blood pressure01:28

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Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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AMINO ACIDS METABOLOMIC SIGNATURE OF BLOOD PRESSURE VARIABILITY In Type 2 Diabetes.

D M Ciobanu1,2, C Bala1,2, A Rusu1,2

  • 1"Iuliu HaČ›ieganu" University of Medicine and Pharmacy, Faculty of Medicine - Diabetes and Nutrition Diseases.

Acta Endocrinologica (Bucharest, Romania : 2005)
|May 8, 2023
PubMed
Summary
This summary is machine-generated.

Specific amino acids (AAs) and their metabolic pathways are linked to blood pressure variability in type 2 diabetes. These findings suggest AAs may serve as biomarkers for hypertension management in diabetic patients.

Keywords:
24 h ambulatory blood pressure monitoringamino acidsblood pressure variabilitydiabetes mellitusmetabolomics

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Area of Science:

  • Metabolomics
  • Endocrinology
  • Cardiovascular Science

Background:

  • Disrupted amino acid (AA) metabolism is implicated in diabetes.
  • The role of serum AAs in diabetes and hypertension requires further investigation due to conflicting data.

Purpose of the Study:

  • To explore serum AAs as potential biomarkers for elevated blood pressure (BP) variability.
  • To assess BP variability using 24-hour ambulatory BP monitoring in type 2 diabetes patients.

Main Methods:

  • Cross-sectional study involving 80 patients with type 2 diabetes.
  • Serum AAs analyzed via targeted metabolomics (UHPLC/MS).
  • 24-hour ambulatory BP monitoring used to assess BP variability, with participants grouped by diastolic BP variability median.

Main Results:

  • Lower levels of aspartic acid, isoleucine, leucine, and phenylalanine, and higher glutamine levels were observed in patients with higher diastolic BP variability.
  • Disrupted pathways included phenylalanine, tyrosine, and tryptophan biosynthesis, phenylalanine metabolism, and alanine, aspartate, and glutamate metabolism.

Conclusions:

  • Specific alterations in serum AAs and their metabolic pathways are associated with increased 24-hour diastolic BP variability in type 2 diabetes.
  • These findings highlight the potential of AAs as biomarkers for managing BP variability in diabetic individuals.