Related Experiment Video
Updated: Jul 31, 2025

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
ST-Elevation Myocardial Infarction Precipitated by Disseminated Intravascular Coagulation: A Therapeutic Challenge
Wahab J Khan1, Dawlat Khan1, Anum Nadeem2
1Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, USA.
Insights
This case study discusses ST-elevation myocardial infarction (STEMI) as a complication of disseminated intravascular coagulation (DIC). It highlights the challenges in managing STEMI when active DIC is present.
Area of Science:
- Cardiology
- Hematology
Background:
- Acute coronary syndrome (ACS) encompasses ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), and unstable angina (UA).
- STEMI is frequently caused by atherosclerotic plaque disruption (Type 1 MI) or other factors like coronary artery spasm or embolism (Type 2 MI).
- STEMI necessitates immediate coronary intervention.
Abstract:
Acute coronary syndrome (ACS) can manifest as ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), and unstable angina (UA). Common etiologies for STEMI include atherosclerotic plaque disruption or erosion manifesting as type 1 myocardial ischemia (MI). Causes of type 2 MI presenting as STEMI may include spontaneous coronary artery dissection, coronary artery spasm, and coronary embolism. STEMI is an emergency mandating immediate coronary intervention. We present a case of STEMI as a complication of disseminated intravascular coagulation (DIC). This case highlights the unique challenge of managing STEMI with active DIC.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Acute Coronary Syndrome IV: Interprofessional Care
Acute Coronary Syndrome I: Introduction
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...

