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Clinical value of the systemic immune-inflammation index in moyamoya disease

Erheng Liu1,2, Chengyuan Liu1,2, Lide Jin2

  • 1Department of Neurosurgery, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Frontiers in Neurology
|May 8, 2023
PubMed
Abstract

Insights

Patients with moyamoya disease (MMD) show elevated inflammatory markers, including the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). These markers may indicate inflammation

Area of Science:

  • Neurology
  • Immunology
  • Vascular Medicine

Background:

  • Moyamoya disease (MMD) is a rare cerebrovascular disorder with an unclear cause.
  • Emerging evidence suggests abnormal immune responses may trigger MMD.
  • Inflammatory markers like NLR, PLR, and SII reflect the immune-inflammation status.

Purpose of the Study:

  • To investigate the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in MMD patients.
  • To assess the potential role of these inflammatory markers in MMD pathogenesis.

Main Methods:

  • A retrospective case-control study included 154 MMD patients and 321 healthy controls.
  • Complete blood count parameters were analyzed to calculate SII, NLR, and PLR.
  • Statistical analysis and ROC curve analysis were performed to evaluate marker significance.

Main Results:

  • MMD patients exhibited significantly higher SII, NLR, and PLR compared to controls (P < 0.001).
  • SII was notably higher in medium-moyamoya vessels than in high or low vessels (P = 0.005).
  • SII demonstrated the highest diagnostic potential for MMD with an AUC of 0.76.

Conclusions:

  • Elevated SII, NLR, and PLR in MMD patients suggest a significant inflammatory component.
  • The middle stage of MMD may involve a more pronounced immune-inflammatory imbalance.
  • Further research is needed to confirm SII's role in MMD diagnosis and as an inflammatory marker.
Keywords:
immuneinflammationmoyamoya diseaseneutrophil/lymphocyte ratioplatelet/lymphocyte ratiosystemic immune-inflammation index

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