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Cellular and Natural Viral Engineering in Cognition-Based Evolution.

Miller W B1, Reber A S2, Marshall P3

  • 1Banner Health Systems - Medicine, Paradise Valley, Arizona, AZ, USA.

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Summary

Cognition-Based Evolution reframes cellular and viral interactions beyond host-parasite dynamics. It proposes that cells and viruses actively co-engineer life through information exchange, driving evolution and development.

Keywords:
Cognition-Based EvolutionNatural Cellular EngineeringNatural Viral Engineeringholobiontsenomevirome

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Area of Science:

  • Evolutionary Biology
  • Virology
  • Cell Biology
  • Systems Biology

Background:

  • Neo-Darwinism views evolution through random genetic variation and natural selection, with host-parasite dynamics governing cell-virome interactions.
  • This perspective limits understanding of the complex, reciprocal relationship between cellular life and viruses.

Purpose of the Study:

  • To introduce Cognition-Based Evolution as an alternative framework for understanding biological development and evolution.
  • To re-evaluate the role of the virome in cellular interactions and evolutionary processes.
  • To propose Natural Viral Engineering as a co-participant with Natural Cellular Engineering.

Main Methods:

  • Conceptual framework development, shifting from random variation to cognition-based information exchange.
  • Analysis of viral-cellular interactions as active cross-communications and resource exchanges.
  • Reinterpretation of genetic transfers and their role in environmental adaptation.

Main Results:

  • Cellular interactions are framed as a cognition-based interactome for self-preservation and homeorhesis.
  • The virome acts as a crucial intermediary, facilitating resource exchange and genetic transfers.
  • Viral-cellular exchanges are nonrandom, adaptive tools for confronting environmental stresses, supporting viral symbiogenesis.

Conclusions:

  • Cognition-Based Evolution offers a new paradigm for viral-cellular dynamics, emphasizing active co-engineering.
  • Pathogenesis is presented as one outcome within a broader scope of Natural Viral Engineering.
  • Natural Viral Engineering is proposed as integral to Natural Cellular Engineering within this new evolutionary model.