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Updated: Jul 31, 2025

Assays for the Degradation of Misfolded Proteins in Cells
Published on: August 28, 2016
[Advances in molecular function of p62 protein and its role in diseases]
Xinying Sui1,2, Ping Xu2,3,4, Changzhu Duan1
1Molecular Medicine and Cancer Research Center, Department of Cell Biology and Genetics, College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.
Abstract:
Sequestosome 1 (SQSTM1/p62) is a selective autophagy adaptor protein that plays an important role in the clearance of proteins to be degraded as well as in the maintenance of cellular proteostasis. p62 protein has multiple functional domains, which interact with several downstream proteins to precisely regulate multiple signaling pathways, thereby linking p62 to oxidative defense systems, inflammatory responses and nutrient sensing. Studies have shown that mutation or abnormal expression of p62 is closely related to the occurrence and development of various diseases, including neurodegenerative diseases, tumors, infectious diseases, genetic diseases and chronic diseases. This review summarizes the structural features and molecular functions of p62. Moreover, we systematically introduce its multiple functions in protein homeostasis and regulation of signaling pathways. Furthermore, the complexity and versatility of p62 in the occurrence and development of diseases are summarized, with the aim to provide a reference for understanding the function of p62 protein and facilitating related disease research.
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