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Updated: Jul 31, 2025

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
Published on: March 17, 2022
Management of Acute Right Ventricular Failure
Ayu Asakage1, Josefine Bækgaard2,3, Alexandre Mebazaa1,3,4,5
1UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), INSERM, Université de Paris Cité, Paris, France.
Acute right ventricular failure (RVF) is a serious condition impacting many patients. This review covers its causes, symptoms, and management, highlighting transthoracic echocardiography as a key diagnostic tool.
Area of Science:
- Cardiology
- Critical Care Medicine
Background:
- Acute right ventricular failure (RVF) is a prevalent clinical condition with significant morbidity and mortality.
- Despite its frequency, the pathophysiology of acute RVF remains incompletely understood, with limited research compared to chronic forms.
- There is a growing clinical and research interest in the right ventricle (RV) and its failure states.
Purpose of the Study:
- To provide a comprehensive and current overview of acute RVF.
- To detail the pathophysiology, clinical presentation, and diagnostic approaches for acute RVF.
- To outline the contemporary management strategies for acute RVF.
Main Methods:
- This review synthesizes current literature on acute RVF.
- Key diagnostic modalities, particularly transthoracic echocardiography (TTE), are discussed.
- Management principles, including etiological treatment and supportive care, are examined.
Main Results:
- Acute RVF is a complex, life-threatening condition with diverse etiologies.
- Transthoracic echocardiography (TTE) is identified as the primary diagnostic tool for identifying the underlying cause of acute RVF.
- Effective management involves prompt etiological treatment and supportive measures, often requiring intensive care unit (ICU) admission for severe cases.
Conclusions:
- Acute RVF necessitates a thorough understanding of its pathophysiology and timely diagnosis.
- Transthoracic echocardiography plays a crucial role in guiding the management of acute RVF.
- Multifaceted management, including etiological treatment and critical care, is essential for improving outcomes in acute RVF.
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