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COVID-19-Associated Coagulopathy: Ascending Aortic Thrombus
Maria E Mesalles1, Shiavax J Rao1, Usman Sagheer1
1Internal Medicine, MedStar Union Memorial Hospital, Baltimore, USA.
Cureus
|May 8, 2023
Summary
Coronavirus disease 2019 (COVID-19) can cause arterial thrombosis. Anticoagulation therapy effectively resolved an aortic thrombus in a COVID-19 patient, highlighting treatment efficacy.
Area of Science:
- Cardiovascular Medicine
- Infectious Diseases
- Hematology
Background:
- The pathogenesis of arterial thrombosis in coronavirus disease 2019 (COVID-19) involves endothelial injury, platelet hyperactivation, and cytokine-driven inflammation.
- Current management strategies for COVID-19-associated thrombosis include surgery with anticoagulation or anticoagulation alone.
Observation:
- A 56-year-old woman with recent COVID-19 infection presented with chest pain and dyspnea.
- Imaging revealed an intraluminal thrombus in the mid ascending aorta.
Findings:
- A multidisciplinary team initiated heparin infusion for the aortic thrombus.
- The patient was transitioned to apixaban.
- Follow-up imaging after three months showed complete resolution of the aortic thrombus.
Implications:
- This case demonstrates the successful management of aortic thrombosis in a COVID-19 patient using anticoagulation.
- Anticoagulation therapy, including apixaban, can be effective in resolving arterial thrombi associated with COVID-19.
- Further research into COVID-19's prothrombotic mechanisms and optimal anticoagulation strategies is warranted.
Keywords:
aortic thrombusarterial thrombusascending aortic thrombuscoagulopathycoronavirus disease 2019covid-19More Related Videos
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