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Updated: Jul 31, 2025

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Published on: October 21, 2018
Measurement of renal cortical fibrosis by CT scan
John D Olson1, Janet A Tooze1, Daniel J Bourland1
1Department of Comparative Medicine, Wake Forest University, Winston-Salem, NC, 27101, USA.
Rationale And Objectives:
The accurate, non-invasive, and rapid measurement of renal cortical fibrosis is needed for well-defined benchmarks of permanent injury and for use of anti-fibrotic agents. It is also needed for non-invasive and rapid assessment of the chronicity of human renal diseases.
Materials And Methods:
We have used a non-human primate model of radiation nephropathy to develop a novel method of size-corrected CT imaging to quantify renal cortical fibrosis.
Results:
Our method has an area under the receiver operating curve of 0.96, which is superior to any other non-invasive method of measuring renal fibrosis.
Conclusion:
Our method is suitable for immediate translation to human clinical renal diseases.
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