The roles and mechanism of m⁶A RNA methylation regulators in cancer immunity

N⁶-methyladenosine (m⁶A), the most common internal modification in RNA, can be regulated by three types of regulators, including methyltransferases (writers), demethylases (erasers), and m⁶A binding proteins (readers). Recently, immunotherapy represented by immune checkpoint blocking has increasingly become an effective cancer treatment, and increasing shreds of evidence show that m⁶A RNA methylation affects cancer immunity in various cancers. Until now, there have been few reviews about the role and mechanism of m⁶A modification in cancer immunity. Here, we first summarized the regulation of m⁶A regulators on the expression of target messenger RNAs (mRNA) and their corresponding roles in inflammation, immunity response, immune process and immunotherapy in various cancer cells. Meanwhile, we described the roles and mechanisms of m⁶A RNA modification in tumor microenvironment and immune response by affecting the stability of non-coding RNA (ncRNA). Moreover, we also discussed the m⁶A regulators or its target RNAs which might be used as predictor of cancer diagnosis and prognosis, and shed light on the potentiality of m⁶A methylation regulators as therapeutic targets in cancer immunity.