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Targeting non-coding RNAs in sEVs: The biological functions and potential therapeutic strategy of diabetic

Nan Ding1, Zhongwei Yin1, Chen Chen1

  • 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 430030, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 8, 2023
PubMed

Insights

Diabetic cardiomyopathy (DCM) involves heart dysfunction in diabetes. Small extracellular vesicle non-coding RNAs (sEV-ncRNAs) show promise as diagnostic and therapeutic targets for DCM.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biochemistry

Background:

  • Diabetic cardiomyopathy (DCM) is a heart condition in diabetic patients, independent of other cardiovascular diseases.
  • DCM is a major cause of death among individuals with diabetes.
  • The exact mechanisms driving DCM remain unclear.

Purpose of the Study:

  • To explore the role of non-coding RNAs (ncRNAs) within small extracellular vesicles (sEVs) in diabetic cardiomyopathy.
  • To review current therapeutic strategies involving sEV-ncRNAs for DCM.
  • To identify limitations and potential improvements in sEV-ncRNA-based therapies for DCM.

Main Methods:

  • Literature review focusing on sEV-ncRNAs and diabetic cardiomyopathy.
  • Analysis of current research on diagnostic and therapeutic applications of sEV-ncRNAs in DCM.
  • Discussion of existing treatment advancements and challenges.

Main Results:

  • Small extracellular vesicles (sEVs) contain non-coding RNAs (ncRNAs) implicated in DCM.
  • sEV-ncRNAs are associated with the development and progression of diabetic cardiomyopathy.
  • These ncRNAs represent potential biomarkers and therapeutic targets for DCM.

Conclusions:

  • sEV-ncRNAs play a significant role in the pathogenesis of diabetic cardiomyopathy.
  • Current therapeutic approaches targeting sEV-ncRNAs for DCM show promise but face limitations.
  • Further research is needed to optimize sEV-ncRNA-based interventions for improved DCM treatment.

Keywords:
Biological functionsDiabetic cardiomyopathyNon-coding RNAsSEVTherapeutic strategy

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