Acute effects of dexamethasone on normal and on posttraumatic spinal cord polysynaptic reflex activity and axonal...

The effects of a single intravenous injection of a high dose of dexamethasone (4 mg/kg) on polysynaptic reflex activity and axonal conduction were measured for 5 hours in the intact and in the compression-injured L-7 spinal cord segment of high spinal cats. The segment was injured by a transient compression of preset degree and duration. In the uninjured preparation, dexamethasone administration significantly reduced polysynaptic reflex size for 2 hours. Axonal conduction was unaltered. One group of injured animals was given dexamethasone 30 minutes after trauma, whereas another was not treated. The acute posttraumatic changes in both parameters did not differ significantly in treated and untreated animals. Histopathologically, differences in the amount of segmental edema and hemorrhage between untreated and treated animals were not significant.