The Brain & Behavior Research Foundation's philanthropic support for neuropsychiatric research

In the 36 years since its founding, the Brain and Behavior Research Foundation (BBRF) has become one of the world's largest non-government funders of grants for neuropsychiatric research. A number of lessons can be drawn from the BBRF experience. One is that scientific competence in the organization, and full control over selection of grantees, has always resided in a Scientific Council composed of leaders in the field. Fund-raising has been conducted separately, and all public dollars contributed have been used to fund grants. The Council has sought to support the best research, no matter who is doing it or where it is being done. Over 80% of 6300 grants awarded have jump-started the careers of young investigators judged to demonstrate unusual promise. These early-career grants have been the equivalent of seed funding, enabling the best and brightest entrants to the field to perform research that, if successful, can provide a basis for much larger, career-sustaining grants. Much of the funded research has been basic research, although many contributions leading to clinical advances have also resulted from BBRF grants. BBRF has learned that it pays to have a diversified research portfolio, with thousands of grantees attacking the problem of mental illness from many different angles. The Foundation's experience also demonstrates the power of patient-inspired philanthropic support. Donors repeatedly express satisfaction that some aspect of mental illness that they care deeply about is being addressed, and find comfort and support from the sense of joining with others in the mission.