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Evolving techniques for reducing phantom limb pain.

Damien P Kuffler1

  • 1Institute of Neurobiology, Medical Sciences Campus, University of Puerto Rico, San Juan 00901, Puerto Rico.

Experimental Biology and Medicine (Maywood, N.J.)
|May 9, 2023
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Summary

Phantom limb pain (PLP) affects up to 90% of amputees. Novel autologous platelet-rich plasma (PRP) techniques show promise for long-term reduction of this chronic neuropathic pain.

Keywords:
Amputation-induced painPLPPRPamputationschronic painpain eliminationplatelet-rich plasma

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Area of Science:

  • Neurology
  • Regenerative Medicine
  • Pain Management

Background:

  • Millions worldwide live with limb loss, with up to 90% experiencing phantom limb pain (PLP) post-amputation.
  • PLP is a severe, chronic neuropathic pain often inadequately managed by current treatments.
  • Amputation triggers central and peripheral nervous system changes contributing to PLP.

Purpose of the Study:

  • To review current understanding of amputation-induced changes causing PLP.
  • To evaluate existing treatments for PLP, noting their limitations.
  • To explore novel therapeutic strategies for long-term PLP relief.

Main Methods:

  • Review of scientific literature on PLP etiology and treatments.
  • Analysis of cellular and molecular mechanisms underlying neuropathic pain after amputation.
  • Investigation of autologous platelet-rich plasma (PRP) as a potential therapeutic agent.

Main Results:

  • Current pharmacological and alternative therapies offer only short-term relief for PLP.
  • Cellular changes and released factors play a crucial role in PLP development.
  • Autologous PRP demonstrates potential for sustained PLP reduction.

Conclusions:

  • Existing PLP treatments are insufficient for long-term pain management.
  • Targeting cellular and neural changes is key to effective PLP treatment.
  • Autologous PRP represents a promising novel approach for long-term phantom limb pain reduction.