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Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
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Sec16 and Sed4 interdependently function as interaction and localization partners at ER exit sites.

Tomohiro Yorimitsu1, Ken Sato1

  • 1Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.

Journal of Cell Science
|May 9, 2023
PubMed
Summary

Sed4, a Sec12 homolog, concentrates at ER exit sites (ERES) and recruits Sec16, a key COPII organizer. Their interaction ensures proper localization, revealing interdependent functions in yeast protein transport.

Keywords:
COPIIERER exit sitesEndoplasmic reticulumSec16Sed4

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