[Pathomorphosis of acute renal insufficiency]

The pathogenetic treatment of acute renal insufficiency (ARI) of the type of "shock kidney" started early in the disease changes the clinico-anatomical picture of ARI. Therapeutically conditioned pathomorphosis of ARI may exist. According to the data of the literature and the author's data based on morphological analysis of 400 autopsy cases of ARI, the ARI pathomorphosis consists of the following : (1) emergence of reversible ARI forms (when the treatment is started early and nephron is not deeply affected); (2) disappearance of some morphological signs of ARI (reaction of the renal tissue to cyclinders, tubulorexis); (3) appearance of unusual regeneration of nephroepithelium in deep affection of the kidneys. Renal changes associated with therapy should be regarded as pathology of ARI therapy.