Related Experiment Video
Updated: Jul 31, 2025
04:55
Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
Published on: May 26, 2023
832
Cardiac Outcome of Children With SARS-CoV-2 Related Multisystem Inflammatory Syndrome
Ali Reza Ghodsi1, Abdolreza Malek2, Soheila Siroosbakht1
1Department of Pediatrics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Indian Pediatrics
|May 10, 2023
Summary
Most children with multisystem inflammatory syndrome (MIS-C) showed cardiac abnormalities at diagnosis, but this significantly improved by six months. Early treatment with IVIG and steroids reduced the risk of cardiac dysfunction in MIS-C patients.
Area of Science:
- Pediatric Cardiology
- Infectious Diseases
- Inflammatory Syndromes
Background:
- Multisystem inflammatory syndrome in children (MIS-C) is a serious condition linked to COVID-19.
- Cardiac involvement is common in MIS-C, necessitating detailed follow-up studies.
Approach:
- This study reviewed hospital records of 116 MIS-C patients (<21 years) with six-month follow-up.
- Echocardiographic findings were analyzed at baseline and six months post-diagnosis.
- Demographic, clinical, laboratory, and treatment data were collected.
Key Points:
- At diagnosis, 70.7% of MIS-C patients had cardiac abnormalities, including valve failure (50.9%) and ventricular dysfunction (39.7%).
- By six months, only 10.3% of patients had persistent cardiac abnormalities.
- Treatment with IVIG and steroids significantly reduced the likelihood of ventricular dysfunction, valve failure, and low ejection fraction compared to IVIG alone.
Conclusions:
- Cardiac abnormalities in MIS-C patients significantly decrease within six months of diagnosis.
- Early intervention with IVIG and steroids appears crucial in mitigating long-term cardiac complications in MIS-C.
More Related Videos
Related Concept Videos
01:23Rheumatic Heart Disease I: Introduction
21
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
21
01:27Myocarditis II: Clinical Features and Diagnostic Tests
13
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
13
01:14Myocarditis III: Medical Management
9
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
9
01:21Myocarditis I: Introduction
12
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
12
01:22Myocarditis IV: Nursing Management
13
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
13
01:30Cardiomyopathy II: Dilated Cardiomyopathy
12
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
12