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Updated: Jul 31, 2025

Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation
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Bioorthogonally Assisted Phototherapy: Recent Advances and Prospects.

Eszter Kozma1, Márton Bojtár1, Péter Kele1

  • 1Chemical Biology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Eötvös Loránd Research Network, Magyar tudósok krt. 2, 1117, Budapest, Hungary.

Angewandte Chemie (International Ed. in English)
|May 10, 2023
PubMed
Summary

Photoresponsive materials combined with bioorthogonal chemistry improve targeted cancer therapy precision. This approach offers enhanced control for treating diffuse tumors, advancing phototherapy research.

Keywords:
ActivatableBioorthogonalCancerPhototherapyTargeting

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Area of Science:

  • Biomedical Engineering
  • Photochemistry
  • Oncology

Background:

  • Photoresponsive materials provide precise spatiotemporal control in biological applications.
  • Phototherapeutic methods are emerging as powerful tools for targeted cancer treatment.
  • Combining photoactivatable strategies with bioorthogonal chemistry enhances therapeutic precision.

Purpose of the Study:

  • To summarize the current state of bioorthogonally assisted phototherapy.
  • To highlight advancements in targeted cancer treatment using photoresponsive materials.
  • To underscore the potential of these methods for diffuse tumor therapies.

Main Methods:

  • Review of recent literature on photoresponsive materials.
  • Analysis of studies combining photoactivatable approaches with bioorthogonal chemistry.
  • Assessment of applications in targeted phototherapies, especially for disperse tumors.

Main Results:

  • Integration of photoactivatable agents and bioorthogonal reactions significantly boosts on-target selectivity.
  • Improved spatial and temporal control is achieved in phototherapy delivery and activation.
  • Demonstrated potential for enhanced efficacy in treating challenging tumor types.

Conclusions:

  • Bioorthogonally assisted phototherapy represents a rapidly advancing field with significant therapeutic promise.
  • Further research is warranted to fully exploit the potential of these advanced targeted therapies.
  • The combination offers a powerful strategy for future cancer treatment modalities.