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Optically Controlled Drug Delivery Through Microscale Brain-Machine Interfaces Using Integrated Upconverting

Levente Víg1, Anita Zátonyi1, Bence Csernyus1

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Researchers integrated upconversion nanoparticles (UCNPs) with brain-machine interfaces for precise, light-activated drug delivery. This novel approach enables simultaneous neural recording and localized substance release near implants.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Neuroscience

Background:

  • Microengineered biomedical implants require advanced drug delivery systems.
  • Upconversion nanoparticles (UCNPs) offer unique optical properties for controlled release applications.

Purpose of the Study:

  • To integrate lanthanide-cored UCNPs onto microelectrocorticography (ECoG) implants.
  • To develop a spatially controlled, optically releasable drug delivery system.
  • To assess the feasibility of UCNP-modified ECoG for simultaneous neural recording and drug release.

Main Methods:

  • Surface modification of UCNPs and immobilization onto silicone-based ECoG implants.
  • Utilizing near-infrared excitable, visible-emitting UCNPs for photochemical reactions.
  • Characterization of UCNP integration, stability (in vitro/in vivo), and impact on electrophysiological function.

Main Results:

  • Successful integration of UCNPs onto ECoG implants.
  • Demonstration of light-induced local dye release via photochemical reactions.
  • Evaluation of UCNP stability and minimal impact on electrophysiological recording capabilities.

Conclusions:

  • UCNP-modified ECoG implants can serve as integrated drug delivery devices.
  • This technology enables localized substance release triggered by optical activation.
  • Potential for simultaneous neural monitoring and targeted therapeutic delivery in brain tissue.