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Primary Cutaneous Actinomycosis: A Diagnostic Enigma
Sulhera Khan1, Bareerah Khan2, Wajeeha Batool3
1Dermatology, Civil Hospital Karachi, Karachi, PAK.
Abstract:
Actinomyces are Gram-positive, filamentous rods found endogenously as a part of the normal flora and can be acquired exogenously as they are present in the soil. The most common species known to infect humans is Actinomyces israelii. Five forms of the disease have been identified so far, of which the primary infection of the skin is the most uncommon. It is also commonly considered one of the most misdiagnosed diseases. We present a case of a young male diagnosed with primary cutaneous actinomycosis based on a histopathology specimen after multiple failed diagnoses of Madura foot/mycetoma, cutaneous tuberculosis, and malignancy. The patient was successfully treated with antibiotics with the restoration of his functional disability caused by the lesion.
Insights
Primary cutaneous actinomycosis, a rare skin infection caused by Actinomyces, is often misdiagnosed. This case highlights successful antibiotic treatment after initial misdiagnoses, improving patient function.
Area of Science:
- Medical Microbiology
- Dermatology
- Infectious Diseases
Background:
- Actinomyces are Gram-positive, filamentous bacteria, part of normal flora, and found in soil.
- Actinomyces israelii is the most common species infecting humans.
- Primary cutaneous actinomycosis is an uncommon manifestation of Actinomyces infection.
Observation:
- A young male presented with symptoms initially misdiagnosed as Madura foot/mycetoma, cutaneous tuberculosis, and malignancy.
- Histopathology confirmed primary cutaneous actinomycosis.
- The patient experienced functional disability due to the skin lesion.
Findings:
- The case highlights the diagnostic challenges of primary cutaneous actinomycosis.
- Histopathological examination is crucial for accurate diagnosis.
- Successful treatment with antibiotics led to the restoration of function.
Implications:
- Early and accurate diagnosis of cutaneous actinomycosis is essential.
- Antibiotic therapy is effective in treating primary cutaneous actinomycosis.
- This case underscores the importance of considering rare infections in differential diagnoses.
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