Personalized mRNA Vaccine Immunogenic against PDAC

    Cancer Discovery
    |May 10, 2023
    PubMed

    BioNTech's personalized mRNA vaccine, autogene cevumeran, elicited neoantigen-specific T cells in eight of 16 patients with surgically resected pancreatic ductal adenocarcinoma, leading to T-cell expansion in the bloodstream and delays in disease recurrence, according to phase I trial data. A randomized follow-up study is planned.