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Related Experiment Videos

Prosthetic valve endocarditis resulting from Nocardia asteroides.

R H Falk, F R Dimock, J Sharkey

    British Heart Journal
    |January 1, 1979
    PubMed
    Summary

    Nocardia asteroides endocarditis can occur even with negative blood cultures after aortic valve replacement. Sulphonamides are recommended for culture-negative cases unresponsive to standard treatments.

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    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Cardiovascular Surgery

    Background:

    • Prosthetic valve endocarditis (PVE) is a serious complication following aortic valve replacement.
    • Nocardia asteroides is an emerging opportunistic pathogen.
    • Diagnosis of PVE can be challenging, especially with negative blood cultures.

    Observation:

    • Nocardia asteroides was identified in the prosthetic valve of a patient who died from endocarditis.
    • The patient had undergone aortic valve replacement.
    • Multiple blood cultures performed prior to death were negative for microbial growth.

    Findings:

    • Nocardia asteroides can cause culture-negative endocarditis, particularly in prosthetic valves.
    • The organism demonstrates sensitivity to sulphonamides.
    • This case highlights a potential cause of PVE missed by standard diagnostic methods.

    Implications:

    • Nocardia asteroides should be considered in cases of culture-negative endocarditis, especially post-cardiac surgery.
    • Early consideration of sulphonamide therapy may be beneficial for PVE unresponsive to conventional treatments.
    • Increased awareness of Nocardia asteroides as a pathogen in PVE is crucial for timely diagnosis and management.

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