Palladium-loaded ceramic membrane-catalyzed flow-through Suzuki-Miyaura reaction

A general Pd-loaded ceramic membrane catalyzed Suzuki-Miyaura reaction in a flow-through membrane reactor is reported for the first time. Versatile (hetero)aryl bromides and chlorides proceeded well with an array of (hetero)aryl boronic acids. The consistently high activity of the catalytic membrane in eight cycles has proved its good stability and recyclability. Synthesis of drug molecules has further demonstrated that the catalytic membrane protocol is a powerful and comprehensive alternative to the traditional Suzuki-Miyaura cross-coupling.