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Updated: Apr 23, 2026
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Palladium-Catalyzed Chemo- and Regioselective 1,2-Alkynylboration of Unactivated Aliphatic Alkenes
Jiacheng Rui1, Xinye Huang2, Ling Zhang2
1State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China.
Abstract:
A palladium-catalyzed 1,2-alkynylboration of unactivated alkenes with alkynyl bromides and B2pin2 is reported. This method efficiently delivers valuable β-boryl-γ-alkynyl and γ-boryl-δ-alkynyl amides with exclusive chemo- and regioselectivities. The reaction accommodates both terminal and internal alkenes, including sterically hindered substrates, and proceeds under mild conditions. Synthetic utility is demonstrated through gram-scale synthesis and diverse downstream transformations of the boryl-alkyne products.
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