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Updated: Aug 5, 2026
28:15
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
Contribution from descriptive studies to the etiological knowledge of colorectal cancer
Sozial- Und Praventivmedizin
|January 1, 1986
Abstract:
Incidence of colorectal cancer increasing exponentially with age is confirmed but sex-age differences in incidence throughout the large bowel are shown. Observations of incidence within countries indicate that colorectal cancer is a disease of affluent societies. Furthermore, it is hypothesized that a high dietary fat intake leads to an increase in faecal components associated with colon cancer risk.
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Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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