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Pigmented villonodular synovitis. A clinicopathologic study of 52 cases
Acta Pathologica Japonica
|March 1, 1986
Summary
Pigmented villonodular synovitis (PVS) most commonly affects the knee and ankle joints. Microscopic analysis reveals characteristic villous projections and histiocyte proliferation, with cells exhibiting macrophage properties.
Area of Science:
- Orthopedics
- Pathology
- Histology
Background:
- Pigmented villonodular synovitis (PVS) is a proliferative disorder of the synovium.
- Understanding the cellular and structural characteristics of PVS is crucial for diagnosis and management.
Purpose of the Study:
- To report clinicopathologic, enzyme histochemical, and electron microscopic findings in patients with PVS.
- To characterize the cellular composition and structural features of PVS.
Main Methods:
- Analysis of 52 patient cases with PVS.
- Inclusion of clinicopathologic, enzyme histochemical, and electron microscopic evaluations.
- Detailed examination of synovial membrane, nodular formations, and cellular morphology.
Main Results:
- PVS predominantly affected the knee (48%) and ankle (25%) joints.
- Microscopy showed villous projections and nodules composed of histiocyte-like cells with phagocytic activity.
- Enzyme histochemistry indicated lesional cells possess macrophage functional properties; electron microscopy identified histiocyte-like, fibroblast-like cells, intermediate cells, and myofibroblasts.
Conclusions:
- PVS is characterized by specific microscopic and ultrastructural features.
- The lesional cells demonstrate macrophage-like characteristics.
- Findings contribute to a comprehensive understanding of PVS pathology.